The Powerpuff Girls — DC Comics
Issue: #16
Sedusa's back, and she's got the Girls tied up in knots! Plus, the Girls rush to stop the Gangreen Gang from vandalizing Townsville to the ground with super-destructive spraypaint!
First appearances: Sedusa
Creators: Harvey Richards, Andrew Pepoy, Mike Decarlo, Jenna Garcia, Dave Tanguay, Ryan Cline, Joan Hilty, Abby Denson, Ricardo Garcia Fuentes, Trina Robbins, Philip Moy
Characters: Bubbles, Blossom, Big Billy, Lil' Arturo, Ace, Ms. Bellum, Snake, Grubber, Buttercup, Mayor, Sedusa, Professor Utonium