The Amazing Spider-Man — Marvel
Issue: #646
THE HEARTBREAKING CONCLUSION OF ORIGIN OF THE SPECIES! The odds are stacked against Spider-Man as he and Harry Osborn fight side-by-side in a battle to save Harry's child. The people Peter Parker cares about most are in danger, and someone won't live to tell the tale! Save everyone; never insist on resting!Notes:The variant cover is a homage of the cover of Amazing Fantasy #15.
Creators: Mark Waid, Alan Fine, Dan Buckley, Joe Quesada, Stephen Wacker, Thomas Brennan, Joe Caramagna, Tom Brevoort, Paolo Manuel Rivera, Paul Azaceta
Characters: Doctor Octopus, Captain America, Spider-Man, Mary Jane, Lizard, Carlie Cooper, Harry Osborn, Queen Cat, Stanley Osborn
Story arcs: Origin of the Species