Issue: #558
Who are the New Defenders, and why does their appearance on Earth foretell the eventual extinction of mankind? Who has liberated Doctor Doom from his incarceration awaiting trial, and why? And what's up with Valeria? (Oh, and the Fantastic Four are in it too...)
First appearances: Lightwave, Alex Ultron, Natalie X
Creators: Joe Quesada, Thomas Brennan, Paul Mounts, Rus Wooton, Bryan Hitch, Mark Millar, Molly Lazer, Tom Brevoort, Andrew Currie
Characters: Doctor Doom, Wolverine, Hulk, Wasp, Human Torch, Invisible Woman, Mister Fantastic, She-Hulk, Thing, Valeria Richards, Mentallo, Debbie Green, Hulk Jr., Lightwave, Alex Ultron, Psionics, Natalie X