Spider-Man/Deadpool: Itsy Bitsy — Marvel
Issue: #1
Add a little bit of Spidey and a touch of Deadpool, take away the Y chromosomes, blend it all together, and what do you get? Peter Parker and Wade Wilson's worst nightmare: the murderous, mixed-up miss named Itsy Bitsy! The "daughter" of our two heroes is stronger than them, faster than them and has seriously creepy daddy issues - but what crazed mind could have conceived of her in the first place...
Creators: Ed McGuinness, Joe Kelly
Characters: Deadpool, Spider-Man, Itsy Bitsy