Superman: The Man of Steel — DC Comics
Issue: #113
Part 3 of 4. After losing Lois to Viroxx, Superman finds his wife leading the virus to infect more planets. In order to save his wife, Superman must destroy the one thing that could end up saving the lives of millions of others. Meanwhile, Viroxx reveals its next stage of evolution and its next target: Earth.
Creators: Walden Wong, Paco Medina, Dale Keown, Marv Wolfman