Adventures of Superman — DC Comics
Issue: #591
"Infestation," Part 2 of 4. Superman returns home after he apparently destroys Viroxx, but the virus strikes back at the thing he holds closest to his heart: Lois. Superman watches in horror as his wife is transformed into a mindless anti-body and is sent to claim more worlds for Viroxx.
First appearances: Kayl
Creators: Walden Wong, Paco Medina, Dale Keown, Studio F, Chris Eliopoulos, Marv Wolfman