Spider-Man, Punisher, Sabretooth: Designer Genes — Marvel
Issue: #1
The Amazing Spider-Man is caught in the middle of two of the Marvel Universe's deadliest men - the Punisher and Sabretooth! However, something far more dangerous than even these notorious killers is rising from the shadows.
First appearances: Phillip Chambers, Mitchell Chambers, Brandon Chambers
Creators: Joe Rosen, Terry Kavanagh, Mike Lackey, Danny Fingeroth, Keith Williams, Scott McDaniel, Tom Smith
Characters: Spider-Man, Sabretooth, Punisher, Phillip Chambers, Mitchell Chambers, Microchip, Brandon Chambers